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Ingredient file // Vitamin or mineral

Choline Bitartrate

Useful choline, with a specific stone caution

Choline bitartrate is a manufactured salt added to supply choline, which dogs need for normal liver and nerve function. A case series links its tartrate portion to a rare urinary stone, making stone history worth checking.

What it is
A powdered salt made from choline and tartaric acid, added to supply choline in food.
Made from
Manufactured choline and tartaric acid
Main job
Supply dietary choline
Typical amount
Not published
Watch for
A history of calcium tartrate stones
Not the same as
Choline chloride

Our read // In our catalog

In 1 of every 649 foods we track

Share of foods that list it

0%

4 of the 2,595 foods with an ingredient list on file, from 2 brands. 3 wet dog food, 1 freeze-dried dog food.

Each square is 1% of the catalog

Where it sits on the label

Median position 18. In the top five of 0 foods, so it is usually a minor ingredient.

Top five List position, heaviest first

Above the salt

100%

Almost always listed before the salt, so there is more of it than a pinch.

Price per lb

Foods with it $12.86
All foods $3.23

Median of the cheapest bag price across 1 priced foods, 298% above the catalog. The price is the food's, not the ingredient's.

Who leans on it

75%

of the foods that list it are from Orijen. 2 brands use it in total.

What it is

How it is made

It is a synthetic chemical, not a food leftover. Makers react trimethylamine and ethylene oxide with tartaric acid, then sell the crystals to food, supplement and feed companies.5

  1. 01 // Source Starting chemicals Tartaric acid is stirred into water and trimethylamine is fed in, forming a trimethylamine tartrate salt.
  2. 02 // Process Ethylene oxide added Ethylene oxide is added at 30 to 70°C, turning that salt into dicholine tartrate.
  3. 03 // Process More tartaric acid A second dose of tartaric acid converts it to choline bitartrate, and the liquid is filtered.
  4. 04 // Output White crystals The filtrate is concentrated and cooled until white crystals form, which are centrifuged and dried.

What is in it

Composition, dry matter

41.1

% choline

The choline share of the pure, dry salt by molecular weight. The rest is bitartrate, which matters for the stone caution.

Choline 41.1%3
Bitartrate 58.9%3
Choline bitartrate assay 99-100.5%6

The choline and bitartrate shares describe a pure, dry molecule; the bitartrate figure is calculated from its published molecular weights. The assay range is a purity specification, not a survey of ingredients delivered to pet food plants.3,6

Why it is in the bag

What the manufacturer gets

  1. 01

    Closes a nutrient gap

    Dogs need choline in the finished diet. A measured addition lets formulators meet the nutrient target when the main ingredients supply too little.4,7

  2. 02

    A stable choline salt

    A manufacturer calls it a relatively stable salt, while choline chloride carries reactive chloride ions and needs purifying before feed use. That is a maker's view, not a comparison test.5

  3. 03

    Offers bulk fortification

    A bulk supplier calls this form more economical than other choline sources. That is a supplier claim, not a published comparison of pet food costs.8

  4. 04

    Keeps the recipe measurable

    The concentrated powder lets a maker adjust choline without changing the meat, eggs or other main ingredients that also contain it.7

How much AAFCO's dog food profiles specify at least 1,360 mg choline per kg of dry food, but no required amount of this particular salt.4

Our read // The claims

What the evidence supports

Strong: controlled studies in dogs agree. Some: small or mixed dog data. Thin: mechanism or lab work only. None: nothing, or the evidence points the other way.

  1. Brands say

    Choline bitartrate supplies a nutrient dogs need

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    The pure salt is 41.1% choline by molecular weight, and AAFCO sets a choline minimum for dog food. Its nutrient job is clear; an ingredient list does not show how much was added.3,4,7

  2. Owners say

    Choline bitartrate causes bladder stones

    Outruns the evidence

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    In a retrospective dog case series, choline bitartrate was the identified tartrate source in 24 of 25 dogs with a known source and a calcium tartrate stone. Exposure doses were unknown, so the study cannot prove cause.1

  3. Brands say

    This form absorbs better than choline chloride

    Outruns the evidence

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    A randomized crossover study in 6 men found no difference in blood choline exposure after equal choline doses from bitartrate and chloride. It did not test dogs, and it gives no basis for claiming a bitartrate advantage.2

  4. Brands say

    It improves a dog's memory

    Outruns the evidence

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    Choline is used to make a nerve signaling chemical, but that does not demonstrate better memory. Placebo-controlled human experiments found no memory improvement after choline bitartrate; no dog memory trial was found.3

Straight answers

What owners ask

  1. Q01

    Is it just filler?

    No

    It supplies choline, a nutrient listed in AAFCO's dog food profiles. Food makers add it to adjust the nutrient level, not to provide bulk or replace a main ingredient.4,7

  2. Q02

    Is bitartrate the same as chloride?

    No

    Both supply choline, but their other components differ. Bitartrate supplies tartrate; chloride does not. That distinction matters most for a dog that has formed a calcium tartrate stone.1,5

  3. Q03

    Should I avoid it for stones?

    For tartrate stones

    If your dog has formed a calcium tartrate stone, the case-series authors recommend removing tartrate sources from food and supplements. The study does not show a risk for an individual dog without that history.1

Who uses it

Brands, best sellers and the company it keeps

Top brands, by foods that list it

  1. Orijen 3
  2. Wysong 1

Usually listed with, share of the foods that list it

  1. Chicken 75%
  2. Kale 75%
  3. Bell Pepper 50%
  4. Pork 50%
  5. Carrots 50%
  6. Sweet Potatoes 50%
  7. Beef 50%
  8. Beef Bone 50%
  9. Chicken Liver 25%
  10. Chicken Heart 25%
  11. Duck 25%
  12. Chicken Bone Broth 25%

Our read // On the bag

Read it as choline, then check stone history

Near the nutrient supplements, choline bitartrate signals a measured addition. Judge the food by its nutritional adequacy statement and the main ingredients above it. If your dog has had a calcium tartrate stone, choose a food that supplies choline without tartrate.

Sources

What we read

Checked October 1, 2026.

  1. 1 Association of Diet and Calcium Tartrate Tetrahydrate Uroliths in Dogs Journal of Veterinary Internal Medicine, 2025 // Journal
  2. 2 Differential metabolism of choline supplements in adult volunteers European Journal of Nutrition, 2021 // Journal
  3. 3 No Acute Effects of Choline Bitartrate Food Supplements on Memory in Healthy, Young, Human Adults PLOS ONE, 2016 // Journal
  4. 4 AAFCO Dog Food Nutrient Profiles Based on Dry Matter AAFCO, 2013 // Regulator
  5. 5 Choline bitartrate and preparation method therefor (WO2020078408A1) Jinan Pengbo Biotechnology Co Ltd, via Google Patents, 2020 // Industry
  6. 6 Choline Bitartrate United States Pharmacopeia, 2025 // Regulator
  7. 7 Substances Added to Food: Choline Bitartrate U.S. Food and Drug Administration, 2026 // Government
  8. 8 DL Choline Bitartrate Technical Data Sheet Jinan Jiuan Ester Chemical Co., Ltd., 2016 // Industry
An ingredient on its own tells you very little. What matters is how much of it there is and where it sits in the list. That is why we weigh the top five rather than reacting to any single name further down. Back to the wiki

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